Association between contrast media volume-glomerular filtration rate ratio and contrast-induced acute kidney injury after primary percutaneous coronary intervention

Celik O., Ozturk D., Akin F., Ayca B., Yalcln A. A., Erturk M., ...More

Angiology, vol.66, no.6, pp.519-524, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.1177/0003319714542277
  • Journal Name: Angiology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.519-524
  • Keywords: contrast media volume-estimated glomerular filtration ratio, contrast-induced acute kidney injury, primary percutaneous coronary intervention
  • Uşak University Affiliated: No

Abstract

We hypothesized that contrast media volume-estimated glomerular filtration rate (CV-e-GFR) ratio may be a predictor of contrast media-induced acute kidney injury (CI-AKI). We investigated the associations between CV-e-GFR ratio and CI-AKI in 597 patients undergoing primary percutaneous coronary intervention (pPCI). An absolute ≥0.3 mg/dL increase in serum creatinine compared with baseline levels within 48 hours after the procedure was considered as CI-AKI; 78 (13.1%) of the 597 patients experienced CI-AKI. The amount of contrast during procedure was higher in the CI-AKI group than in those without CI-AKI (153 vs 135 mL, P =.003). The CV-e-GFR ratio was significantly higher in patients with CI-AKI than without (2.3 vs 1.5, P <.001). In multivariate analysis, independent predictors of CI-AKI were low left ventricular ejection fraction (P =.018, odds ratio [OR] = 0.966), e-GFR <60 mL/min (P =.012, OR = 2.558), and CV-e-GFR >2 (P <.001, OR = 5.917). In conclusion, CV-e-GFR ratio is significantly associated with CI-AKI after pPCI.