Atıf İçin Kopyala
Karavana H. A., Rençber S., Karavana S. Y., Yalçın F.
The 6th International Conference on Advanced Materials and Systems ICAMS 2016, Bucuresti, Romanya, 20 - 22 Ekim 2016, ss.257-262
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Yayın Türü:
Bildiri / Tam Metin Bildiri
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Basıldığı Şehir:
Bucuresti
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Basıldığı Ülke:
Romanya
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Sayfa Sayıları:
ss.257-262
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Uşak Üniversitesi Adresli:
Hayır
Özet
It is important for a therapeutic shoe to have a wearable quality and its comfortable use is also
prominent in terms of providing an increase in user's quality of life. In long-term treatment of
diseases, medical products which are to be manufactured with medical leather materials might be a
prominent alternative via local effect application as an adjuvant to the treatment. It is aimedin this
study to produce microparticles(MPs) which contain the active agent chlorhexidine digluconateand
application of these MPson lining leather for manufacturing diabetic shoes while providing them a
functional quality. Withinthe scope of the project, MPs loaded with drugs were obtained via spraying
chlorhexidine digluconate(CHD)active agent and through spraying with ethyl cellulose polymer and
ustulation.In vitro characterisation studies were performed on the acquired MPs. Additionally, active
agent quantitation andin vitro drug delivery studies were also performed. Following the studies, the
determined optimum MPformulations were applied on the leather, then existenceand efficiency of
MPs within the leather was shown in thesubsequent studiesIt is important for a therapeutic shoe to have a wearable quality and its comfortable use is also
prominent in terms of providing an increase in user's quality of life. In long-term treatment of
diseases, medical products which are to be manufactured with medical leather materials might be a
prominent alternative via local effect application as an adjuvant to the treatment. It is aimedin this
study to produce microparticles(MPs) which contain the active agent chlorhexidine digluconateand
application of these MPson lining leather for manufacturing diabetic shoes while providing them a
functional quality. Withinthe scope of the project, MPs loaded with drugs were obtained via spraying
chlorhexidine digluconate(CHD)active agent and through spraying with ethyl cellulose polymer and
ustulation.In vitro characterisation studies were performed on the acquired MPs. Additionally, active
agent quantitation andin vitro drug delivery studies were also performed. Following the studies, the
determined optimum MPformulations were applied on the leather, then existenceand efficiency of
MPs within the leather was shown in thesubsequent studies