Synthesis, experimental and theoretical analysis, and antiproliferative activity of 2-(4-methoxyphenylamino)-2-oxoethyl methacrylate


Tanış E., ÇANKAYA N., Yalçın S.

Chinese Journal of Physics, vol.57, pp.348-361, 2019 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 57
  • Publication Date: 2019
  • Doi Number: 10.1016/j.cjph.2018.11.006
  • Journal Name: Chinese Journal of Physics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.348-361
  • Keywords: 2-(4-methoxyphenylamino)-2-oxoethyl methacrylate (MPAEMA), Antiproliferative activity, Density functional theory, HeLa cell line, Time-dependent approach
  • Uşak University Affiliated: Yes

Abstract

In this study 2-(4-methoxyphenylamino)-2-oxoethyl methacrylate (MPAEMA) has been synthesized and characterized experimentally (FTIR, NMR). Theoretically, physical, electronic and vibrational properties of MPAEMA molecule have been investigated using density functional theory (DFT) calculations at B3LYP/6-311++G(d,p) basis set. Bond distance, FTIR spectrum, NMR spectra and vibrational frequencies have been carried out. The calculated FTIR and NMR spectra of the headline molecule from the DFT have been compared with the measured ones, and good results have been obtained. UV spectrum characteristics and the electronic properties, like frontier orbitals, and band gap energy of MPAEMA have also been recorded by time-dependent (TD-DFT) method based on optimized structure with different solvent. The experimental results have been compared with theoretical values. Both experimental and theoretical methods have shown that the compound has successfully been synthesized. Cytotoxicity of MPAEMA has been investigated by XTT cell proliferation assay. IC50 values of MPAEMA have been identified as 1.8 mM on HeLa cell line.