Design of leather footwear for diabetics containing chlorhexidine digluconate microparticles

Yalçın F., Karavana H. A., Rencber S., Karavana S. Y.

Journal of the American Leather Chemists Association, cilt.115, sa.3, ss.79-86, 2020 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 115 Sayı: 3
  • Basım Tarihi: 2020
  • Dergi Adı: Journal of the American Leather Chemists Association
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chimica, Compendex, DIALNET
  • Sayfa Sayıları: ss.79-86
  • Uşak Üniversitesi Adresli: Evet

Özet

ChlorHexidine Digluconate [CHD] was encapsulated inside an ethylcellulose shell material [Aquacoat ECD], and then spray dried to produce mixed microparticles (MPs). The validity and functional quality of the resultant [CHD-MPs] were analyzed on vamp and lining leather which are used to manufacture shoes for diabetics. The morphology, efficiency of encapsulation and in vitro release characteristics of the [CHD-MPs] were optimized in order to impregnate [CHD-MPs] onto leather footwear for diabetics. Scanning electron microscopy (SEM) was used to characterize the [CHD-MPs] and the leathers treated with it. SEM images illustrated that the [CHD-MPs] were spherical, smooth in shape and adhered well to leather. In vitro CHD-release studies from its MPs, and for leather treated with it were performed in phosphate buffer saline at pH =7.2. There was an inherently controlled release behaviour of CHD for all the formulations on leather. Finally, microbiologic studies on leather treated with [CHD-MPs] were done. This study suggested that footwear containing [CHD-MPs] is/will improve the quality of daily life for diabetics.