Predictive role of de ritis ratio in biochemical recurrence after radical prostatectomy Radikal prostatektomi sonrası biyokimyasal rekürrens tahmininde de ritis oranının rolü

Karamık K., Aktaş Y., Yıldız A., Erol İ., İslamoğlu E., Ateş M., ...Daha Fazla

Haseki Tip Bulteni, cilt.58, sa.1, ss.84-93, 2020 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/haseki.galenos.2019.5592
  • Dergi Adı: Haseki Tip Bulteni
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.84-93
  • Anahtar Kelimeler: Biochemical recurrence, Biochemical recurrence-free survival, De Ritis ratio, Pathological findings, Prostate cancer
  • Uşak Üniversitesi Adresli: Hayır

Özet

Aim: To analyze the role of De Ritis (aspartate aminotransferase/ alanine aminotransferase) ratio in predicting biochemical recurrence (BCR) after radical prostatectomy (RP). Methods: We retrospectively evaluated 425 patients with localised prostate cancer who underwent RP from 2009 to 2018. Patients with neo-adjuvant treatment, elevated liver enzymes, postoperative early hormone therapy, incomplete clinicopathological data and a follow-up of less than 6 months were excluded from the study. Demographic, clinical, pathological and follow-up data of the patients were recorded. Patients with and without BCR were compared. Sensitivity and specificity of De Ritis ratio in predicting BCR were calculated. Results: According to the maximum value of the Youden index, optimal threshold of De Ritis ratio for BCR was 1.1. Sensitivity, specificity, positive predictive value and negative predictive value were 69.7%, 61.1%, 37.6% and 85.7%, respectively. Multivariate analysis showed that the De Ritis ratio (HR=1.968, p=0.014) was a significant predictor factor for BCR. BCR-free survival rate was significantly lower in patients with higher De Ritis ratio. Conclusion: Our study suggests that elevated De Ritis ratio and detailed pathological findings could be an independent predictive factor for BCR after RP.