Evaluation of antimicrobial activity of three endemic Salvia species growing in Turkey Türkiye’de yetişen Üç endemik Salvia türünün antimikrobiyal aktivitesinin değerlendirilmesi

Güzel S., Özay Y., Ülger M., KAHRAMAN A., Aslan G.

Hacettepe University Journal of the Faculty of Pharmacy, vol.38, no.1, pp.4-10, 2018 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 1
  • Publication Date: 2018
  • Journal Name: Hacettepe University Journal of the Faculty of Pharmacy
  • Journal Indexes: Scopus
  • Page Numbers: pp.4-10
  • Keywords: Antimicrobial activity, Broth microdilution method, Plant extract, Salvia species
  • Uşak University Affiliated: Yes

Abstract

The ethanol extracts obtained from the aerial parts of three Salvia species (S. hypargeia, S. huberi and S. dichroantha) which are endemic to Turkey were tested for their antibacterial and antifungal activities against two Gram (+) bacterial strains [Staphylococcus aureus (ATCC 25925), Bacillus subtilis (ATCC 6633)]; three Gram (-) bacterial strains [Escherichia coli (ATCC 25923), Acinetobacter baumannii (ATCC 02026), Aeromonas hydrophila (ATCC 95080)] and Mycobacterium tuberculosis H37Rv, and three fungal strains (Candida glabrata ATCC 90030, C. parapsilosis ATCC 22019, C. tropicalis ATCC 750) by using the broth microdilution method. All tested plant extracts showed significantly antibacterial activity against A. baumannii (ATCC 02026) (62.5 μg/mL MIC value) when compared to reference drug Ampicillin (125 μg/mL MIC value). The ethanolic extract of S. huberi was found the most effectiveness extract against M. tuberculosis H37Rv with 0.97 μg/mL MIC value when compared to reference antimycobacterial agents Isoniazid and Ethambutol (0.97 μg/mL and 1.95 μg/mL MIC values, respectively).