Olive leaf extract loaded silk fibroin/hyaluronic acid nanofiber webs for wound dressing applications

Basal G., TETİK G., Kurkcu G., BAYRAKTAR O., Gurhan I., Atabey A.

Digest Journal of Nanomaterials and Biostructures, vol.11, no.4, pp.1113-1123, 2016 (SCI-Expanded, Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 4
  • Publication Date: 2016
  • Journal Name: Digest Journal of Nanomaterials and Biostructures
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1113-1123
  • Keywords: Electrospinning, Hyaluronic acid, Olive leaf extract, Silk fibroin, Wound dressing
  • Uşak University Affiliated: Yes

Abstract

In this study a novel wound contact layer was developed by entrapping polyphenols obtained from olive leaf extract (OLE) inside the nanofibers made from the blend of hyaluronic acid and silk fibroin, produced by co axial electrospinning method. OLE has powerful antibacterial, anti fungal and antiviral properties and also known as a good antioxidant. The purpose of coaxial electrospinning was to achieve the controlled release of OLE by capturing it inside nanofibers. TEM images confirmed that OLE was successfully captured. Release profile of OLE loaded nanofibers indicated an initial burst release followed by a more gradual release. In vitro cytotoxicity tests indicated that the developed electrospun coaxial nanofibers were non-toxic.