Comparison of vitamin D, parathyroid hormone, and body composition in obese premenopausal and postmenopausal women


Çaykara Peran B., Adil H., Öztürk G., Sargın M., Mutlu H. H.

ENDOCRINE, cilt.91, sa.1, 2026 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 91 Sayı: 1
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1007/s12020-026-04652-1
  • Dergi Adı: ENDOCRINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
  • Anahtar Kelimeler: Obesity, Vitamin D, Premenopause, Postmenopause
  • Uşak Üniversitesi Adresli: Evet

Özet

Purpose: We aimed to investigate the associations of serum vitamin D and parathyroid hormone (PTH) with body composition parameters, including bone weight and mineral content, in obese premenopausal and postmenopausal women. Methods: In this retrospective study, 200 pre-menopausal and 200 post-menopausal obese women were evaluated. Body composition was assessed using a bioelectrical impedance analyzer (TANITA-48M), and biochemical parameters were measured by standard laboratory methods. Results: The mean serum vitamin D level was significantly lower in pre-menopausal women compared with post-menopausal women (16.91 ± 13.17 vs. 22.59 ± 16.49 ng/mL, p < 0.05). Overall, 83.75% (n = 335) of the study population had vitamin D deficiency or insufficiency, while only 16.25% (n = 65) demonstrated normal vitamin D levels. BMI did not differ significantly between the two groups (p > 0.05). In pre-menopausal women, serum vitamin D levels were negatively correlated with PTH and mineral content. In post-menopausal women, vitamin D levels showed a negative correlation with BMI, body weight, body fat percentage, and PTH (p < 0.05). Conclusions: The prevalence of hypovitaminosis D was remarkably high (83.75%) among obese women. Moreover, declining vitamin D levels were associated with increased body weight and adiposity, as well as elevated PTH.