Isolation and characterization of antitumor alkaloid from poppy capsules (Papaver somniferum)

Bulduk I., Taktak F. F.

Journal of Chemistry, 2013 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1155/2013/493870
  • Dergi Adı: Journal of Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Uşak Üniversitesi Adresli: Evet

Özet

Noscapine, a phthalideisoquinoline alkaloid derived from opium, has been used in the treatment of various cancer types. Its low-toxicity profile has increased attention to this alkaloid. With regard to increasing demand for this compound, we developed a new method for isolation of noscapine from dried capsules of Papaver somniferum. Noscapine was successfully isolated from poppy capsules for the first time and the purity of the isolated compound was determined to be over 99.59 by HPLC analysis. The structure of noscapine was confirmed by H 1 NMR, C 13 NMR, FT-IR, elemental analysis, and HR-ESI-MS methods. © 2013 Ibrahim Bulduk and Fulya Taktak.