Research Information System
Clinica e Investigacion en Arteriosclerosis, vol.32, no.6, pp.256-262, 2020 (ESCI)
Aim: To investigate the relationship between glomerular filtration rates (GFR), and homeostasis model assesment of insulin resistance (HOMA-IR), C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) in patients with polycystic ovary syndrome (PCOS). Material and methods: Thirty-one overweight and obese PCOS patients with body mass index (BMI) ≥ 25 kg/m2 and 25 non-obese PCOS patients with BMI < 25 kg/m2 were included into patients’ group, while 23 overweight and obese, and 25 non-obese age-and BMI-matched healthy individuals (aged between 18 and 40 years), were enrolled as controls. Levels of serum creatinine, glucose, insulin, CRP, and complete blood count were measured. eGFR, HOMA-IR and NLR were also calculated. Results: In PCOS group, HOMA-IR (p = 0.001), CRP (p = 0.025) and waist hip ratio (WHR) (p = 0.011) were higher than controls. In obese PCOS sub-group, HOMA-IR (p = 0.004) and WHR (p = 0.002) were higher than obese controls. In non-obese PCOS sub-group, HOMA-IR (p = 0.001) were higher than non-obese controls. In obese PCOS sub-group; HOMA-IR (p = 0.001) and CRP (p = 0.001) levels were significantly higher than non-obese PCOS sub-group. In terms of other parameters, no significant difference was found between the groups. The analysis showed a negative correlation between GFR, and BMI and HOMA-IR in PCOS group, between GFR, WHR and insulin levels in obese PCOS sub-group, and between BMI, and HOMA-IR and NLR in non-obese PCOS sub-group. Conclusion: Although HOMA-IR and CRP were higher in PCOS group, there was no difference in NLR and GFR levels between those with PCOS and controls.