Mathematical Modeling Of Stem Cell Therapy For Left Ventricular Remodeling After Myocardial Infarction

Büyükkahraman M. L., Chen-Charpentier c. M., Liao J., Kojouharov H. V.

Journal of Mechanics in Medicine and Biology, vol.23, no.6, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 6
  • Publication Date: 2023
  • Doi Number: 10.1142/s0219519423400158
  • Journal Name: Journal of Mechanics in Medicine and Biology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Biotechnology Research Abstracts, Communication Abstracts, Compendex, Metadex, Civil Engineering Abstracts
  • Keywords: cardiomyocytes, cytokines, heart regeneration, immune system, Myocardial infarction, nonlinear ODE, stem cell therapy
  • Uşak University Affiliated: Yes

Abstract

The heart is an organ with a limited capacity for regeneration and repair. In this paper, a new mathematical model is presented to study the left ventricular remodeling after myocardial infarction (MI) and followed stem cell therapeutic effort. The model represents the post-MI regeneration process of cardiomyocytes under stem cell therapy with oxygen restoration. The resulting system of nonlinear ordinary differential equations (ODE) is studied numerically in order to demonstrate the functionality and performance of the new model. The optimal time of stem cell injection for various oxygen restorations is determined. Moreover, the regeneration of cardiomyocytes is successfully correlated with improved left ventricle function observed in experiments. The proposed nonlinear ODE model is able to capture the complicated biological interactions in post-MI remodeling and can serve as a platform for in silico simulation and perturbation to optimize MI stem cell therapy.