Akademik Veri Yönetim Sistemi
Kocatepe Veterinary Journal, cilt.16, sa.3, ss.383-392, 2023 (Hakemli Dergi)
In this study, it was aimed to investigate the antioxidant activities and histopathological effects of the aqueous and ethanolic extracts obtained from the endemic Sideritis akmanii plant, which spreads on the Şuhut-Sandıklı road in the Kumalar plateau region of Afyonkarahisar province. The number of 48 Wistar albino male rats were divided into 8 groups; Control Group (Group I), CMC Group (Group II), 0.5% CMC (carboxymethyl cellulose), Aqueous and ethanolic plant extract groups (Group III-IV-V-VI-VII-VIII). Three different doses (1%, 2%, and 4%) extracts from the determined LD50 dose were applied to 6 experimental groups for 30 days. At the end of the experiment, malondialdehyde (MDA), glutathione (GSH) levels, superoxide dismutase (SOD), and catalase (CAT) enzyme activities were measured in healthy rat's blood and tissue (liver, heart, brain, kidney, testis) samples. The whole blood MDA level decreased in all doses of the ethanolic extract group compared to the control group, while the GSH level increased in both extract groups compared to the control group. SOD and CAT enzyme activities were increased in the ethanolic groups compared to the control group, except for erythrocyte and testis tissue (p<0.05). On the other hand, no changes were observed in the histopathological examination results. As a result of the study, it was observed that the aqueous and ethanolic extracts of Sideritis akmanii had antioxidant properties and the ethanolic extract was more effective on antioxidant enzymes.