SERUM APELIN-13 LEVELS ARE DECREASED AMONG ADOLESCENTS DIAGNOSED WITH MAJOR DEPRESSIVE DISORDER

Creative Commons License

AÇIKEL S. B., ARTIK A., Hosoglu E., Yerlikaya F. H.

Psychiatria Danubina, vol.33, no.4, pp.677-681, 2022 (SCI-Expanded, SSCI, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.24869/psyd.2022.677
  • Journal Name: Psychiatria Danubina
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, EMBASE, Psycinfo, Social services abstracts
  • Page Numbers: pp.677-681
  • Keywords: biological markers, child/adolescent, depression, mood disorders
  • Open Archive Collection: AVESIS Open Access Collection
  • Uşak University Affiliated: Yes

Abstract

Background: Apelin-13 have potential effect on mood because of high expression in the hypothalamus. In this study, we aimed to investigate the serum apelin-13 levels among adolescents with major depressive disorder. Subject and methods: A total of 42 patients between the ages of 12 and 18 with a primary diagnosis of major depressive disorder have been included. Depression scores of both groups were measured by the Children's Depression Inventory. Serum apelin-13 concentrations were measured by a commercially available kit based on enzyme-linked immunosorbent assay (ELISA) method. Results: The mean serum apelin-13 levels in the patients with MDD was 173.08±106.33 pg/ml, whereas it was 251.75±167.82 pg/ml in healthy controls. The difference between groups in terms of mean serum apelin-13 levels was statistically significant (p=0.018, Cohen's d=-0.571). Conclusion: This is the first study to examine the serum apelin-13 levels in adolescents diagnosed with major depressive disorder. Lower serum apelin-13 levels were found in depressed adolescents.