Research Information System
Hacettepe Journal of Biology and Chemistry, vol.45, no.4, pp.509-514, 2017 (Peer-Reviewed Journal)
Asimple, accurate, precise and economical capillary electrophoresis method has been developed for estimation of Sertraline in pharmaceutical dosage form. The estimation of Sertraline was done at 205 nm in pH 4.0 phosphate buffer. In the developed method, linearity over the concentration range of 1-12 µg.mL-1 of Sertraline was observed. The linear regression was found to be 0.999. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method. The precision (intra-day and inter-day) of method was found within limits (RSD < 2%). The sensitivity of the method was assessed by determining limit of detection and limit of quantification. It could be concluded from the results obtained in the present investigation that the method for estimation of Sertraline in pharmaceutical dosage form is simple, rapid, accurate, precise, green and economical, also it could be used, successfully, in the quality control of pharmaceutical formulations and other routine laboratory analysis.