A novel triple-responsive hydrogels based on 2-(dimethylamino) ethyl methacrylate by copolymerization with 2-(N-morpholino) ethyl methacrylate

Taktak F., YILDIZ M., Sert H., SOYKAN C.

Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, vol.52, no.1, pp.39-46, 2015 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1080/10601325.2014.976747
  • Journal Name: Journal of Macromolecular Science, Part A: Pure and Applied Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.39-46
  • Keywords: 2-(dimethylamino) ethyl methacrylate, 2-(N-morpholino) ethyl methacrylate, swelling study salt-responsive shrinking kinetic, Triple responsive
  • Uşak University Affiliated: Yes

Abstract

A novel triple responsive copolymer hydrogels composed of 2-(dimethylamino) ethyl methacrylate and 2-(N-morpholino) ethyl methacrylate monomers were prepared through free radical polymerization. The structure and morphology of the hydrogels were examined by using infrared spectroscopy (ATR-IR) and scanning electron microscopy (SEM). It was found that poly (DMAEMA-co-MEMA) hydrogels exhibited pH-dependent smart swelling and shrinking behavior in buffer solutions which is ascribed to the protonation/deprotonation of the tertiary amine pendant groups of both monomers. The copolymerization of more hydrophobic MEMA monomer with hydrophilic DMAEMA monomer created associated micro domain in the hydrogel structure which is able to induce reversible phase transition of the hydrogel. Therefore, poly (DMAEMA-co-MEMA) hydrogels displayed rapidly responses to the increasing temperature and divalent salt effects by shrink-type behavior. Such a multi-responsive network structure would be very beneficial for biomedical applications. © 2015