Exploring the uncharted potential of sea plants for diabetes management: Advances, challenges, and future directions
Trends in Food Science and Technology, cilt.173, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 173
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.tifs.2026.105778
- Dergi Adı: Trends in Food Science and Technology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Compendex, DIALNET, Academic Search Ultimate (EBSCO), Engineering Source (EBSCO)
- Anahtar Kelimeler: Marine-derived compounds, Macroalgae metabolites, Seagrass, Insulin modulation, Sustainable therapeutics, Natural products
- Uşak Üniversitesi Adresli: Evet
Özet
Background: The rising global burden of diabetes mellitus, especially type 2 diabetes, highlights the necessity of new, safe, and sustainable treatment approaches that will not be limited to traditional pharmacological treatment options. An unexploited source of structurally diversified biologically potent antidiabetic compounds is marine ecosystems, particularly sea plants, which include macroalgae (seaweeds) and seagrasses. Scope and approach: This review is a critical analysis of current progress in the identification, isolation and characterization of marine macroalgae- and seagrass-derived bioactive metabolites that deal with the regulation of glucose, insulin sensitivity, oxidative stress, as well as inflammation. These compounds have an effect on major metabolic pathways. Mechanistic understanding of their mechanisms of action is supported by evidence from in vitro, in vivo, and emerging clinical studies. Simultaneously, the issues of compound standardization, bioavailability, regulatory approval, and environmental sustainability, marine biodiversity protection, and ethical bioprospecting were discussed. Key findings and conclusions: This review presents compelling original insights and calls on international research to invest more in developing marine biotechnology and to develop effective clinical and regulatory infrastructure to achieve the full antidiabetic potential of marine macroalgae and seagrass. With the incorporation of molecular science, environmental management and health concerns on a global scale, marine-derived bioactives can become a revolutionary frontier in the prevention and treatment of diabetes and its related complications.