Cytotoxic sesquiterpene coumarins from the roots of heptaptera cilicica

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TOSUN F., AYTAR E. C., Beutler J. A., Wilson J. A., Miski M.

Records of Natural Products, cilt.15, sa.6, ss.529-536, 2021 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 6
  • Basım Tarihi: 2021
  • Doi Numarası: 10.25135/rnp.242.21.02.1990
  • Dergi Adı: Records of Natural Products
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, ABI/INFORM, CAB Abstracts, EMBASE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.529-536
  • Anahtar Kelimeler: Apiaceae, Cytotoxic activity, Heptaptera cilicica, Sesquiterpene coumarins
  • Uşak Üniversitesi Adresli: Evet

Özet

Preliminary 2-day cancer cell screening assays indicated that the dichloromethane extract of the roots of Heptaptera cilicica showed relatively strong cytotoxic activity. Eleven sesquiterpene coumarin ethers with potent and selective cytotoxic activities were isolated from the dichloromethane extract of the roots of H. cilicica. Furthermore, revised spectroscopic data for 14′-acetoxybadrakemone (4) and complete NMR spectroscopic assignments for colladonin (6) and colladin (7) are reported.