In vitro cytotoxicity in A549, Hepg2, MCF-7, and DLD-1 cancer cell lines and ADME/toxin analysis of a benzimidazole derivative

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BİLİCİ E., AKKOÇ S.

JOURNAL OF KING SAUD UNIVERSITY - SCIENCE, cilt.37, sa.2, ss.1-6, 2025 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 37 Sayı: 2
• Basım Tarihi: 2025
• Doi Numarası: 10.25259/jksus_424_2024
• Dergi Adı: JOURNAL OF KING SAUD UNIVERSITY - SCIENCE
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, zbMATH, Directory of Open Access Journals
• Sayfa Sayıları: ss.1-6
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Uşak Üniversitesi Adresli: Evet

Özet

The development of novel, targeted, and low toxicity therapeutic agents is crucial in addressing cancer, which remains a significant global health issue. Benzimidazole derivates have drawn significant interest owing to their structurer similarity to biological nucleotides and several biological roles, including anticancer activity. This study synthesized a benzimidazole derivative (se-182) and tested its anticancer activities on four cancer cell lines i.e., A549 (lung carcinoma), MCF-7 (breast carcinoma), HepG2 (Liver carcinoma) and Dld-1 (colorectal carcinoma) in vitro.