The Role of Systemic Immune Inflammation Index for Predicting Saphenous Vein Graft Disease in Patients with Coronary Artery Bypass Grafting

Dogdus M., Dindas F., Yenercag M., Yildirim A., Ozcan Abacioglu O., Kilic S., ...More

Angiology, vol.74, no.6, pp.579-586, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 74 Issue: 6
  • Publication Date: 2023
  • Doi Number: 10.1177/00033197221129356
  • Journal Name: Angiology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Food Science & Technology Abstracts
  • Page Numbers: pp.579-586
  • Keywords: lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, saphenous vein graft disease, systemic immune inflammation index
  • Uşak University Affiliated: Yes

Abstract

As inflammation plays a significant role in the development of coronary artery disease, we hypothesized that there may be a relation between the systemic immune inflammation index (SII) and saphenous vein graft disease (SVGD). The study population consisted of 716 consecutive patients who underwent elective coronary angiography (CAG) >1 year after bypass grafting. The patients were divided into 2 groups depending on the extent of SVG patency. SII value was significantly higher in the SVGD(+) group compared with the SVGD(−) group (P <.001). In multivariate logistic regression analysis, SII (P <.001, odds ratio (OR) = 3.27, 95% CI = 1.94–5.65) and neutrophil-to-lymphocyte ratio (NLR) (P <.001, OR = 2.08, 95% CI = 1.59–3.11) were found to be independent predictors of SVGD. An SII value of >935 (x103/ml) has 89.2% sensitivity and 70.6% specificity for the prediction of the SVGD, and an NLR value of >4.15 has 54.6% sensitivity and 68.5% specificity for the prediction of the SVGD. The AUC of SII was found to be greater than the AUC of NLR (P =.002), platelet-to-lymphocyte ratio (PLR) (P =.009), lymphocyte-to-monocyte ratio (LMR) (P =.013), MPV (P =.011), and C-reactive protein (CRP) (P =.034) in predicting SVGD. In conclusion, we demonstrated that SII, which is among the new inflammation indexes, is a more reliable predictor in determining SVGD than the NLR, PLR, and LMR.