Akademik Veri Yönetim Sistemi
Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, cilt.29, sa.2, ss.243-248, 2022 (Hakemli Dergi)
Objective The role of cytokines and chemokines in the pathogenesis of periodontitis indicates that tumor necrosis factor alpha (TNF-α) and macrophage inflammatory protein 1α (MIP1α) have crucial functions in the initiation and progression of periodontitis. However, the cytokine and chemokine profiles of different grades of periodontitis are still unclear, and no conclusive information has yet been reported on biomarkers associated with the progression rate of periodontitis. Thus, the aim of the present study was to estimate the gingival crevicular fluid (GCF) levels of MIP-1α and TNF-α in Grades A, B, and C and to evaluate their role as reliable biomarkers in determining the grade of periodontitis. Materials and Methods Individuals were divided into three groups according to their grade of periodontitis: individuals diagnosed as Stage IV periodontitis with Grade A (Grade A, n = 21), individuals diagnosed as Stage IV periodontitis with Grade B (Grade B, n = 21), and individuals diagnosed as Stage IV periodontitis with Grade C (Grade C, n = 21). Results Although there were no significant differences between groups in terms of mean TNF-α levels, the mean MIP- 1α level of Grade C was significantly higher than that of Grade B and Grade A. The mean MIP-1α level of Grade B was significantly higher than that of Grade A (p < 0.05, Kruskal–Wallis test). Conclusion MIP-1α could have clinical utility as a screening biomarker for the grade of periodontitis.