Akademik Veri Yönetim Sistemi
Mediterr J Rheumatol , cilt.36, sa.2, ss.273-280, 2025 (ESCI)
Objective: Behçet’s disease (BD) may experience heightened pain sensitivity, potentially related to centralsensitisation (CS). The hypersensitive central nervous system causes physical inactivity and kinesiopho-bia due to overreacting to stimuli that would not usually cause pain. This study aims to determine the fre-quency of CS in patients with BD and to evaluate the relationship between CS and kinesiophobia, exercisecapacity, disease activity, and quality of life (QoL).Methods: The study, which included 55 patients with BDand 55 healthy controls (HCs), employed a comprehensive approach. All participants were administeredthe Tampa Kinesiophobia Scale (TKS), the 6-minute walk test (6MWT), and the central sensitisation inven-tory. Results: CS was detected in 61.4% of with BD. Among the 55 patients, 24 (45.5%) were male, with amedian age of 42 years (IQR 17) and a median disease duration of 8 years (IQR 10). Compared to age- andgender-matched HCs, patients with BD exhibited higher CS, increased kinesiophobia, and shorter walkingdistances. There were moderate correlations between CS scores and the 6MWT, TKS, BDCAF, and BDQoLin patients with BD (Rho = 0.51, Rho = 0.56, Rho = 0.48, and Rho = 0.56, respectively; all p-values < .001).Hierarchical linear regression analysis demonstrated a significant association between QoL and the pres-ence of CS (95% Confidence Interval (CI) 0.033-0.562, p=0.028) and kinesiophobia (95% CI 0.245-0.766, p< 0.001). Conclusion: The prevalence of CS and kinesiophobia in BD patients is a significant finding, shed-ding light on the factors contributing to reduced QoL and functional exercise capacity.