Multisegmental Tissue Doppler Imaging and Biochemical Indicators in Thalassemia Major Talasemi Majorda Çok Segmentli Doku Doppler ve Biyokimyasal Göstergeler
Guncel Pediatri, vol.24, no.1, pp.16-26, 2026 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 24 Issue: 1
- Publication Date: 2026
- Doi Number: 10.4274/jcp.2025.52223
- Journal Name: Guncel Pediatri
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Page Numbers: pp.16-26
- Keywords: doku doppler görüntüleme, T2* MRI, T2* MRI, Talasemi, Thalassemia, tissue Doppler imaging
- Open Archive Collection: AVESIS Open Access Collection
- Uşak University Affiliated: Yes
Abstract
Introduction: Since heart failure is among the most important mortality reasons among Thalassemia Major patients, these patients must be regularly checked for heart problems. Our study was planned to compare pulse wave doppler images and segmental tissue doppler images from 8 different areas and their copeptin, NT-pro ANP, NT-proBNP, CK-MB, and ultra-sensitive troponin I value with those of healthy individuals. Materials and Methods: Fifty-nine Thalassemia Major patients over the age of 10, who were asymptomatic concerning cardiac symptoms, were divided into two groups (Group 1T2*<20 msn and Group 2: >20 msn). Echocardiography data and biochemical parameters of patient groups were compared with the control group. Results: In both patient groups, NT-proBNP values were found to be significantly higher compared to the control group (p<0.001), and no correlation was found between NT-proBNP and cardiac MRI. In tissue doppler imaging of lateral and medial sections of the mitral annulus, it was seen that IVCT and IVRT measurements of both patient groups were extended and Myocardial Performance Index (MPI) measurements were increased. E´, A´, and S measurements of Group 1 were found to be lower compared to the control group. There were no significant differences between the groups in terms of copeptin, NT-proANP, CK-MB, and US-Troponin I values. Conclusion: Investigated biochemical indicators could not be strongly correlated with iron accumulation. By calculating MPI values with tissue doppler echocardiography, global cardiac dysfunction may be identified earlier and chelation therapy may be revised.