Antibacterial activity of essential oil from Zingiber officinale Roscoe against Xanthomonas strains: chemical composition and docking study of α-zingiberene

Pereira G. C. S., Fernandes C. C., Pereira J. L., Gonçalves D. S., Calefi G. G., Martins C. H. G., ...Daha Fazla

Journal of Toxicology and Environmental Health - Part A: Current Issues, cilt.88, sa.22, ss.893-905, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 88 Sayı: 22
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1080/15287394.2025.2514533
  • Dergi Adı: Journal of Toxicology and Environmental Health - Part A: Current Issues
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Agricultural & Environmental Science Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Environment Index, MEDLINE, Metadex, Pollution Abstracts, Public Affairs Index, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.893-905
  • Anahtar Kelimeler: Agricultural chemicals, agricultural pathogens, biobactericide, plant disease, α-zingiberene
  • Uşak Üniversitesi Adresli: Evet

Özet

Ginger rhizomes (Zingiber officinale Roscoe) have been used for treating several diseases including headaches, colds, nausea, and emesis. Considering the agrochemical potential of essential oil from ginger (EO-ZO), this study aimed to chemically characterize and assess its in vitro anti-Xanthomonas spp. activities. Xanthomonas species are plant pathogens capable of inducing certain diseases, such as canker, necrosis, and gall. For the first time, data demonstrated that EO-ZO exhibited high activity against Xanthomonas citri, X. euvesicatoria, X. vasicola and X. campestris since its minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values ranged between 1.25 and 6.5 µg/ml. GC-MS and GC-FID revealed that α-zingiberene (50%), neral (15%), geranial (11%), and 1,8-cineole (9%) are the major constituents. A structure-based virtual screening approach was applied to α-zingiberene to predict antibacterial activity in silico and confirm its activity. In summary, EO-ZO appears to be a promising antimicrobial agent that may be used in sustainable and environmentally friendly agriculture.