Immunosuppressive therapy induced coronary vasospasm and acute myocardial infarction in a patient undergoing new renal transplantation

Biyik İ., Akturk I. F., Yalcin A. A., Celik O., Oner E.

Postepy w Kardiologii Interwencyjnej, vol.11, no.2, pp.141-145, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.5114/pwki.2015.52288
  • Journal Name: Postepy w Kardiologii Interwencyjnej
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.141-145
  • Keywords: Mycophenolate mofetil, ST segment elevation myocardial infarction, Tacrolimus, Transplantation, Vasospasm
  • Uşak University Affiliated: No

Abstract

Immunosuppressant agents such as calcineurin inhibitors (CNI) used after solid organ transplantation may cause endothelial dysfunction, and coronary and renal arterial vasospasm. We report a patient presenting acute ST segment elevation myocardial infarction (STEMI) at the second week of renal transplantation. In the case of STEMI in patients with solid organ transplants under immunosuppressive therapy with CNI, coronary vasospasm associated with these drugs should be kept in mind before starting any interventional procedure. High dose nitroglycerine may immediately resolve tacrolimus or cyclosporine A induced coronary vasospasm. Calcium channel blockers should immediately be added to treatment because of the short half-life of nitroglycerine.