Can Systemic Immune-Inflammation Index (SII) be a prognostic factor of Bell’s palsy patients?

Kınar A., Ulu Ş., Bucak A., Kazan E.

Neurological Sciences, vol.42, no.8, pp.3197-3201, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 8
  • Publication Date: 2021
  • Doi Number: 10.1007/s10072-020-04921-5
  • Journal Name: Neurological Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CINAHL, EMBASE, Index Islamicus, MEDLINE, Psycinfo
  • Page Numbers: pp.3197-3201
  • Keywords: Bell’s palsy, Facial paralysis, Inflammation, Neutrophil-to-lymphocyte ratio (NLR), Platelet-to-lymphocyte ratio (PLR), Systemic immune-inflammation index (SII)
  • Uşak University Affiliated: No

Abstract

Objective: Recent studies showed that the neutrophil-to-lymphocyte ratio (NLR) and that platelet-to-lymphocyte ratio (PLR) can be used as inflammatory markers in Bell’s palsy. In this study, the aim is to investigate a novel inflammatory index, the Systemic Immune-Inflammation Index (SII), defined as SII = platelets × neutrophils/lymphocytes, in Bell’s palsy patients. Study design: Retrospective. Setting: Clinical research center. Patients: The study included 88 Bell’s palsy patients and 50 healthy controls. Interventions: Patients diagnosed with Bell’s palsy from 2010 to 2019 in a university hospital and an age- and sex-matched healthy control group were included in the study retrospectively. A complete blood count was performed for all participants. Magnetic resonance imaging was applied for Bell’s palsy patients for the exclusion of other diagnoses. Main outcome measures: The CBC parameters were analyzed and hemoglobin, erythrocytes, leukocytes, neutrophils, lymphocytes, and platelet counts were measured. The PLR, NLR, and SII values were calculated with the formula. Results: The patient group had higher neutrophil counts and higher SII and NLR values than the control group (p < 0.05). Also, SII value is a prognostic factor in Bell’s palsy in our study. Conclusions: Bell’s palsy has an inflammatory component. The SII value can indicate an inflammatory condition in these patients. It may be used as a marker and prognostic indicator in Bell’s palsy.