Genel Tip Dergisi, cilt.36, sa.2026, 2026 (Scopus, TRDizin)
Aim: To evaluate the prenatal characteristics, associated anomalies, and postnatal outcomes of fetuses diagnosed with aberrant right subclavian artery (ARSA) during routine obstetric ultrasonography. Methods: This retrospective study included 39 fetuses diagnosed with ARSA between 2022 and 2025 at a tertiary perinatology clinic. Prenatal ultrasound findings, results of genetic testing, and postnatal unfavourable outcomes—including neonatal intensive care admission, dysphagia, respiratory symptoms, and the need for surgical intervention—were investigated. Results: ARSA was an isolated finding in 64.1% of fetuses, while 35.9% had additional anomalies, most commonly single umbilical artery (28.6%), intracardiac echogenic focus (21.4%), and polyhydramnios (21.4%). Amniocentesis was performed in 28.2% of cases, with trisomy 21 identified in one fetus presenting with multiple anomalies. Of all cases, 97.4% resulted in live births. Postnatal unfavourable outcomes presented in 12.8% of cases, and 15.4% required neonatal intensive care. Among the fetuses with unfavorable outcomes, only one was an isolated case of ARSA, while all other fetuses were associated with additional prenatal anomalies. Conclusions: Isolated fetal ARSA is typically associated with a favorable perinatal prognosis and, in the absence of accompanying sonographic abnormalities, should be regarded as a benign anatomical variant or soft marker rather than a definitive indicator of underlying pathology. However, the presence of additional structural findings significantly increases the risk of genetic and postnatal negative outcomes, underscoring the importance of comprehensive prenatal evaluation and multidisciplinary counseling.