Immunohistochemical distribituon of COX-1, COX-2, and TGFβ-1 in the duodenum of rats treated with capsaicin Capsaicin uygulanan sıçanların duodenumda COX-1, COX-2 ve TGFβ-1’in immünohistokimyasal dağılımı
Kafkas Universitesi Veteriner Fakultesi Dergisi, vol.22, no.3, pp.333-338, 2016 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 22 Issue: 3
- Publication Date: 2016
- Doi Number: 10.9775/kvfd.2015.14559
- Journal Name: Kafkas Universitesi Veteriner Fakultesi Dergisi
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.333-338
- Keywords: Capsaicin, Cyclooxygenase, Duodenum, Transforming growth factor β-1
- Uşak University Affiliated: No
Abstract
The purpose of this study was to investigate the effects of capsaicin on the duodenal distribution of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and Transforming growth factor β-1 (TGFβ-1) in rats. Rats were divided into two groups (n =10 in each group). Experimental group treated with capsaicin (1 mg/kg, subcutaneously) was injected in 10% ethanol, 1% Tween and 80% distilled water everyday for a period of one week and in not injected control group. Localisations of COX-1, COX-2 and TGFβ-1 were observed in villus and crypt ephitelial cells, and smooth muscle cells. In conclusion, in this study, capsaicin administration was found to increase the release of COX-1 and COX-2, and TGFβ-1.