Immunohistochemical distribituon of COX-1, COX-2, and TGFβ-1 in the duodenum of rats treated with capsaicin Capsaicin uygulanan sıçanların duodenumda COX-1, COX-2 ve TGFβ-1’in immünohistokimyasal dağılımı

Bakir B., Eliş Yildiz S., Karadağ Sari E., ASKER H., Nazli M.

Kafkas Universitesi Veteriner Fakultesi Dergisi, cilt.22, sa.3, ss.333-338, 2016 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.9775/kvfd.2015.14559
  • Dergi Adı: Kafkas Universitesi Veteriner Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.333-338
  • Anahtar Kelimeler: Capsaicin, Cyclooxygenase, Duodenum, Transforming growth factor β-1
  • Uşak Üniversitesi Adresli: Hayır

Özet

The purpose of this study was to investigate the effects of capsaicin on the duodenal distribution of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and Transforming growth factor β-1 (TGFβ-1) in rats. Rats were divided into two groups (n =10 in each group). Experimental group treated with capsaicin (1 mg/kg, subcutaneously) was injected in 10% ethanol, 1% Tween and 80% distilled water everyday for a period of one week and in not injected control group. Localisations of COX-1, COX-2 and TGFβ-1 were observed in villus and crypt ephitelial cells, and smooth muscle cells. In conclusion, in this study, capsaicin administration was found to increase the release of COX-1 and COX-2, and TGFβ-1.