Behçet's disease as a causative factor of cerebral venous sinus thrombosis: Subgroup analysis of data from the VENOST study

Uluduz D., Midi I., Duman T., Colakoglu S., Tüfekci A., Bakar M., ...Daha Fazla

Rheumatology (United Kingdom), cilt.58, sa.4, ss.600-608, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1093/rheumatology/key153
  • Dergi Adı: Rheumatology (United Kingdom)
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.600-608
  • Anahtar Kelimeler: Behcet's disease, cerebral venous sinus thrombosis, outcome, subgroup analysis, VENOST study
  • Uşak Üniversitesi Adresli: Evet

Özet

Objective. This study was performed to determine the rate of cerebral venous sinus thrombosis (CVST) among cases of Behç et's disease (BD) included in a multicentre study of cerebral venous sinus thrombosis (VENOST). Methods. VENOST was a retrospective and prospective national multicentre observational study that included 1144 patients with CVST. The patients were classified according to aetiologic factors, time of CVST symptom onset, sinus involvement, treatment approach and prognosis. Results. BD was shown to be a causative factor of CVST in 108 (9.4%) of 1144 patients. The mean age of patients in the BD group was 35.27 years and 68.5% were men, whereas in the non-BD CVST group, the mean age was 40.57 years and 28.3% were men (P < 0.001). Among the aetiologic factors for patients aged 1836 years, BD was predominant for men, and puerperium was predominant for women. The onset of symptoms in the BD group was consistent with the subacute form. The transverse sinuses were the most common sites of thrombosis, followed by the superior sagittal sinuses. The most common symptom was headache (96.2%), followed by visual field defects (38%). Conclusions. BD was found in 9.4% of patients in our VENOST series. Patients with BD were younger and showed a male predominance. The functional outcome of CVST in patients with BD was good; only 12% of patients presenting with cranial nerve involvement and altered consciousness at the beginning had a poor outcome (modified Rankin Score 52).