Genotoxic effects of bismuth (III) oxide nanoparticles by allium and comet assay
Chemosphere, cilt.93, sa.2, ss.269-273, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 93 Sayı: 2
- Basım Tarihi: 2013
- Doi Numarası: 10.1016/j.chemosphere.2013.04.076
- Dergi Adı: Chemosphere
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.269-273
- Anahtar Kelimeler: Allium, Chromosome aberration, Comet, DNA damage
- Uşak Üniversitesi Adresli: Evet
Özet
Genotoxic effects of Bismuth (III) oxide nanoparticles (BONPs) were investigated on the root cells of Allium cepa by Allium and Comet assay. A. cepa roots were treated with the aqueous dispersions of BONPs at five different concentrations (12.5, 25, 50, 75, and 100. ppm) for 4. h. Exposure of BONPs significantly increased mitotic index (MI) except 12.5. ppm, total chromosomal aberrations (CAs) in Allium test. While stickiness chromosome laggards, disturbed anaphase-telophase and anaphase bridges were observed in anaphase-telophase cells, pro-metaphase and c-metaphase in other cells. A significant increase in DNA damage was also observed at all concentrations of BONPs except 12.5. ppm by Comet assay. The results were also analyzed statistically by using SPSS for Windows; Duncan's multiple range test was performed. These results indicate that BONPs exhibit genotoxic activity in A. cepa root meristematic cells. © 2013 Elsevier Ltd.