Association of serum elabela levels with carotid artery stenosis in patients with non-cardioembolic ischemic stroke

Dindas F., Koyuncu I., Ocek L., Ozdemir A. V., Yllmaz H., Abacloglu O. O., ...Daha Fazla

Biomarkers in Medicine, cilt.16, sa.8, ss.623-631, 2022 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 8
  • Basım Tarihi: 2022
  • Doi Numarası: 10.2217/bmm-2021-0865
  • Dergi Adı: Biomarkers in Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.623-631
  • Anahtar Kelimeler: atherosclerosis, carotid artery stenosis, elabela, stroke
  • Uşak Üniversitesi Adresli: Evet

Özet

Aim: Elabela (ELA) is a peptide of the apelinergic system and is known to play a role in endothelial homeostasis and vascular pathobiology. In this study, the relationship between carotid artery stenosis, which is the main culprit, and ELA level in patients with non-cardioembolic ischemic stroke was investigated. Materials & methods: Cross-sectional observation included two groups of 40 patients with critical carotid artery stenosis and 40 patients with age-sex matched noncritical carotid artery stenosis. Results: ELA levels were significantly higher in the noncritical stenosis group. ELA had a significantly moderate negative correlation with the carotid score (r =-0.334, p = 0.003), maximal carotid plaque length (r =-0.413, p < 0.001) and degree of stenosis (r =-0.397, p < 0.001). Conclusions: There is a significant inverse correlation between critical carotid artery disease and ELA level in patients with non-cardioembolic ischemic stroke.