Association of serum elabela levels with carotid artery stenosis in patients with non-cardioembolic ischemic stroke

Dindas F., Koyuncu I., Ocek L., Ozdemir A. V., Yllmaz H., Abacloglu O. O., ...More

Biomarkers in Medicine, vol.16, no.8, pp.623-631, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 8
  • Publication Date: 2022
  • Doi Number: 10.2217/bmm-2021-0865
  • Journal Name: Biomarkers in Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.623-631
  • Keywords: atherosclerosis, carotid artery stenosis, elabela, stroke
  • Uşak University Affiliated: Yes

Abstract

Aim: Elabela (ELA) is a peptide of the apelinergic system and is known to play a role in endothelial homeostasis and vascular pathobiology. In this study, the relationship between carotid artery stenosis, which is the main culprit, and ELA level in patients with non-cardioembolic ischemic stroke was investigated. Materials & methods: Cross-sectional observation included two groups of 40 patients with critical carotid artery stenosis and 40 patients with age-sex matched noncritical carotid artery stenosis. Results: ELA levels were significantly higher in the noncritical stenosis group. ELA had a significantly moderate negative correlation with the carotid score (r =-0.334, p = 0.003), maximal carotid plaque length (r =-0.413, p < 0.001) and degree of stenosis (r =-0.397, p < 0.001). Conclusions: There is a significant inverse correlation between critical carotid artery disease and ELA level in patients with non-cardioembolic ischemic stroke.