Encapsulated chlorhexidine digluconate usage on the diabetic footwear upper leathers
34th International Union of Leather Technologists and Chemist Societies Congress, IULTCS 2017, Chennai, Hindistan, 5 - 08 Şubat 2017, ss.43-51, (Tam Metin Bildiri)
- Yayın Türü: Bildiri / Tam Metin Bildiri
- Basıldığı Şehir: Chennai
- Basıldığı Ülke: Hindistan
- Sayfa Sayıları: ss.43-51
- Anahtar Kelimeler: Chlorhexidine digluconate, Diabetic shoes, Encapsulation, Upper leather
- Uşak Üniversitesi Adresli: Evet
Özet
It is important for a therapeutic shoe to have a wearable quality and its comfortable use is also prominent in terms of providing an increase in user's quality of life. In long-term treatment of diseases, medical products which are to be manufactured with medical leather materials might be a prominent alternative via local effect application as an adjuvant to the treatment. It is aimed in this study to produce micro-particles which contain the active agent chlorhexidine digluconate and application of these micro-particles on upper leather for manufacturing diabetic shoes while providing them a functional quality. Within the scope of the project, micro-particles loaded with drugs were obtained via spraying chlorhexidine digluconate active agent and through spraying with ethyl cellulose polymer and ustulation. In vitro characterisation studies were performed on the acquired microparticles. Additionally, active agent quantitation and in vitro drug delivery studies were also performed. Following the studies, the determined optimum microparticle formulations were applied on the leather, then existence and efficiency of microparticles within the leather was shown in the subsequent studies.