Oleuropein alleviates malathion-induced oxidative stress and DNA damage in rats

Karabag-Coban F., BULDUK İ., LİMAN R., Ince S., Cigerci I., Hazman O.

Toxicological and Environmental Chemistry, cilt.98, sa.1, ss.101-108, 2016 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 98 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1080/02772248.2015.1110156
  • Dergi Adı: Toxicological and Environmental Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.101-108
  • Anahtar Kelimeler: DNA damage, malathion, oleuropein, oxidative stress, rat
  • Uşak Üniversitesi Adresli: Evet

Özet

The effects of acute exposure to 250 mg/kg malathion and the protective effects of 20 mg/kg oleuropein, both administered intraperitoneally, were evaluated in Wistar male rats. Malathion administration increased malondialdehyde, nitric oxide, 8-hydroxy-2′-deoxyguanosine, total oxidant status, and DNA damage, yet decreased total antioxidant activity, superoxide dismutase, and catalase activities in blood, liver, and kidney. Administration of oleuropein reversed malathion-induced oxidative stress, lipid peroxidation, DNA damage, and antioxidant enzyme activity.