Oleuropein alleviates malathion-induced oxidative stress and DNA damage in rats
Toxicological and Environmental Chemistry, cilt.98, sa.1, ss.101-108, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 98 Sayı: 1
- Basım Tarihi: 2016
- Doi Numarası: 10.1080/02772248.2015.1110156
- Dergi Adı: Toxicological and Environmental Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.101-108
- Anahtar Kelimeler: malathion, oleuropein, oxidative stress, DNA damage, rat
- Uşak Üniversitesi Adresli: Evet
Özet
The effects of acute exposure to 250 mg/kg malathion and the protective effects of 20 mg/kg oleuropein, both administered intraperitoneally, were evaluated in Wistar male rats. Malathion administration increased malondialdehyde, nitric oxide, 8-hydroxy-2′-deoxyguanosine, total oxidant status, and DNA damage, yet decreased total antioxidant activity, superoxide dismutase, and catalase activities in blood, liver, and kidney. Administration of oleuropein reversed malathion-induced oxidative stress, lipid peroxidation, DNA damage, and antioxidant enzyme activity.