Structural characterization and biological activity profile of carbon quantum dots synthesized using Capparis spinosa L. Extract
Journal of Molecular Structure, cilt.1381, 2027 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 1381
- Basım Tarihi: 2027
- Doi Numarası: 10.1016/j.molstruc.2026.147721
- Dergi Adı: Journal of Molecular Structure
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, INSPEC, Academic Search Ultimate (EBSCO), Engineering Source (EBSCO)
- Anahtar Kelimeler: Acetylcholinesterase inhibition, Carbon quantum dots, Cell viability, DPPH radical scavenging, Capparis spinosa, Tyrosinase inhibition
- Uşak Üniversitesi Adresli: Evet
Özet
In this study, carbon quantum dots (CS-CQDs) were synthesized via a green hydrothermal method using Capparis spinosa L. extract as a natural carbon precursor. The biological activities of CS-CQDs were evaluated through antioxidants, enzyme inhibition, and cytotoxicity assays. CS-CQDs exhibited notable DPPH radical scavenging activity with an IC₅₀ value of 1.12 mg/mL. Enzyme inhibition studies revealed strong acetylcholinesterase inhibitory activity (IC₅₀ = 1.45 mg/mL) and moderate tyrosinase inhibition (IC₅₀ = 19.03 mg/mL). Cytotoxic effects were investigated against MiaPaCa-2, A549, HT-29, and HEK-293 cell lines. CS-CQDs reduced cell viability in a concentration-dependent manner, with IC₅₀ values ranging from 3.311 to 7.531 mg/mL. Although significant differences were observed among cell lines, the cytotoxic effects occurred mainly at relatively high concentrations, indicating limited anticancer selectivity. Overall, the synthesized CS-CQDs exhibited moderate cytotoxic activity, as well as good antioxidant and acetylcholinesterase (AChE) inhibitory properties. These findings highlight the potential of green-synthesized C. spinosa-derived CQDs as sustainable nanomaterials for future biomedical and biotechnological applications.