A Multidisciplinary Approach to Coronavirus Disease (COVID-19)

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Gediz Erturk A., Sahin A., Bati Ay E., Pelit E., Bagdatli E., Kulu I., ...More

Molecules (Basel, Switzerland), vol.26, no.12, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 26 Issue: 12
  • Publication Date: 2021
  • Doi Number: 10.3390/molecules26123526
  • Journal Name: Molecules (Basel, Switzerland)
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Metadex, Veterinary Science Database, Directory of Open Access Journals, Civil Engineering Abstracts
  • Keywords: COVID-19, cytokine storm, dietary supplements, immunotherapy, in-silico research, natural products, repurposing drugs, SARS-CoV-2, small drugs, vaccine development
  • Uşak University Affiliated: Yes

Abstract

Since December 2019, humanity has faced an important global threat. Many studies have been published on the origin, structure, and mechanism of action of the SARS-CoV-2 virus and the treatment of its disease. The priority of scientists all over the world has been to direct their time to research this subject. In this review, we highlight chemical studies and therapeutic approaches to overcome COVID-19 with seven different sections. These sections are the structure and mechanism of action of SARS-CoV-2, immunotherapy and vaccine, computer-aided drug design, repurposing therapeutics for COVID-19, synthesis of new molecular structures against COVID-19, food safety/security and functional food components, and potential natural products against COVID-19. In this work, we aimed to screen all the newly synthesized compounds, repurposing chemicals covering antiviral, anti-inflammatory, antibacterial, antiparasitic, anticancer, antipsychotic, and antihistamine compounds against COVID-19. We also highlight computer-aided approaches to develop an anti-COVID-19 molecule. We explain that some phytochemicals and dietary supplements have been identified as antiviral bioproducts, which have almost been successfully tested against COVID-19. In addition, we present immunotherapy types, targets, immunotherapy and inflammation/mutations of the virus, immune response, and vaccine issues.