SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SCHIFF AND AZO-SCHIFF BASE LIGANDS

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Jadama A., YÜKSEKDANACI S., Astley D., Yasa I.

Studia Universitatis Babes-Bolyai Chemia, vol.2023, no.1, pp.75-89, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 2023 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.24193/subbchem.2023.1.06
  • Journal Name: Studia Universitatis Babes-Bolyai Chemia
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Central & Eastern European Academic Source (CEEAS)
  • Page Numbers: pp.75-89
  • Keywords: amide, amino acid, azo-Schiff base, biological activity, Schiff base
  • Uşak University Affiliated: Yes

Abstract

Schiff and azo-Schiff base derivatives were synthesized, identified and evaluated for their antimicrobial and antifungal activities against gram-positive bacteria, gram-negative bacteria and fungi such as Escherichia coli, Pseudomonas aureginosa, Staphylococcus aureus, Bacillus cereus, Salmonella typhimurium, Saccharomyces cerevisiae and Candida albicans. Chiral amides (2a-e) were synthesised by using D-Phenylglycine, L-Phenylalanine, L-valine, L-isoleucine and L-methionine. Experimental studies include the use of chiral amide derivatives (2a-e) of the five amino acids to synthesize the Schiff and azo-Schiff base derivatives of amides (3a-e, 4a-c and 4e). The structures of the compounds were determined by spectroscopic analyses (FTIR,1H-NMR, 13 C-NMR) and elemental analysis. Among the tested compounds, compound 3b and 3d were found to show the most potent inhibitory action against Gram positive and Gram negative bacteria.