Akademik Veri Yönetim Sistemi
Cancer Treatment Modalities: An Interdisciplinary Approach, Rezaei Nima, Editör, Springer, Cham, Berlin, ss.231-249, 2024
External beam radiation has long been a linchpin in cancer treatment, demanding not just efficacy in tumor control but also precision to minimize damage to healthy tissues. To achieve this, several methods have been developed, such as particle therapy, stereotactic body radiation therapy, and intensity-modulated radiation therapy.
Recent studies in technology and research into radiobiology have focused on three distinct modalities: GRID radiotherapy, microbeam radiotherapy, and ultra-high dose rate radiotherapy. These new methods are also called spatial fractionation. A type of external beam radiation therapy known as GRID radiotherapy uses sieve-like collimators and non-uniform dose distribution. By delivering high-dose and dose rate beams that are micron-sized, the application of spatially fractionated beams, also referred to as Microbeam radiation therapy, has the potential to raise the therapeutic ratio. FLASH radiotherapy uses ultra-high dose rate radiation on the target to reduce radiation-induced toxicity.
These methods, each of which has unique physical and biological bases, collectively offer a comprehensive approach to achieving effective tumor control while protecting healthy tissues. The most crucial topic in all these studies is normal tissue toxicity. Because of this, research is being done on biological response mechanisms in addition to ultra-high dose rate. The critical relationship between clinical results and physical parameters in the tumor and normal tissue response is the subject of ongoing study. The research involves the biological basis and modeling the dose-effect to better understand these relationships.
These innovative methods, based on technology and biological research, could be acknowledged as a significant development in the history of radiation treatment and could have great potential going forward